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Anti-ATF6 Antibody Picoband®, Biotin Conjugate

CAT:
519-A00655-3-Biotin
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-ATF6 Antibody Picoband®, Biotin Conjugate - image 1

Anti-ATF6 Antibody Picoband®, Biotin Conjugate

  • Background: ATF6, a member of the leucine zipper protein family, is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. This gene is mapped to chromosome 1q23.3. ATF6 can constitutively induce the promoter of glucose-regulated protein (grp) genes through activation of the endoplasmic reticulum (ER) stress element (ERSE).
  • Description: Boster Bio Anti-ATF6 Antibody Picoband® catalog # A00655-3. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
  • Synonyms: Cyclic AMP-dependent transcription factor ATF-6 alpha;cAMP-dependent transcription factor ATF-6 alpha;Activating transcription factor 6 alpha;ATF6-alpha;Processed cyclic AMP-dependent transcription factor ATF-6 alpha;ATF6;
  • Gene Name: Cyclic AMP-dependent transcription factor ATF-6 alpha
  • Gene ID: 22926
  • UniProt: P18850
  • Host: Rabbit
  • Reactivity: Human,Mouse,Rat
  • Cross Reactivity: No cross-reactivity with other proteins
  • Immunogen: E.coli-derived human ATF6 recombinant protein (Position: A423-Q670).
  • Clonality: Polyclonal
  • Tissue Specificity: Ubiquitous.
  • Applications: ELISA,Flow Cytometry,IF,ICC,WB
  • Purification: Immunogen affinity purified.
  • Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
  • Form: Lyophilized
  • Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
  • Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N (9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. .
  • Components: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
  • References & Citations: 1. Li, M.; Baumeister, P.; Roy, B.; Phan, T.; Foti, D.; Luo, S.; Lee, A. S. : ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Molec. Cell. Biol. 20: 5096-5106, 2000. 2. Thameem, F.; Farook, V. S.; Bogardus, C.; Prochazka, M. : Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes 55: 839-842, 2006.
  • Storage Conditions: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.
  • Calculated Molecular Weight: 74585 MW
  • Observed Molecular Weight: 90-100 kDa
  • Fragment: Rabbit IgG
  • Applications Notes: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/ml, -
  • Subcellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • Protein Name: Cyclic AMP-dependent transcription factor ATF-6 alpha