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Anti-TNFRSF1A Antibody Picoband®, Biotin Conjugate

CAT:
519-A00294-Biotin
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-TNFRSF1A Antibody Picoband®, Biotin Conjugate - image 1

Anti-TNFRSF1A Antibody Picoband®, Biotin Conjugate

  • Background: Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as TNFR1, is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. The TNFR1 gene is mapped to 12pter-cen. It encodes a protein of 455 amino acids. And this receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
  • Description: Boster Bio Anti-TNFRSF1A Antibody Picoband® catalog # A00294. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
  • Synonyms: Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor 1;TNF-R1;Tumor necrosis factor receptor type I;TNF-RI;TNFR-I;p55;p60;CD120a;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1;TBPI;TNFRSF1A;TNFAR, TNFR1;
  • Gene Name: Tumor necrosis factor receptor superfamily member 1A
  • Gene ID:  7132
  • UniProt: P19438
  • Host: Rabbit
  • Reactivity: Human,Mouse,Rat
  • Cross Reactivity: No cross-reactivity with other proteins.
  • Immunogen: E.coli-derived human TNFRSF1A recombinant protein (Position: F89-N145). Human TNFRSF1A shares 67.3% and 69.1% amino acid (aa) sequence identity with mouse and rat TNFRSF1A, respectively.
  • Clonality: Polyclonal
  • Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
  • Applications: WB
  • Purification: Immunogen affinity purified.
  • Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
  • Form: Lyophilized
  • Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
  • Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • Components: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
  • References & Citations: 1. Baker E, Chen LZ, Smith CA, Callen DF, Goodwin R, Sutherland GR (Nov 1991). "Chromosomal location of the human tumor necrosis factor receptor genes". Cytogenet Cell Genet 57 (2-3): 117–8. 2. Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (Jun 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell 61 (2): 361–70.
  • Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
  • Calculated Molecular Weight: 50495 MW
  • Observed Molecular Weight: 60 kDa
  • Fragment: Rabbit IgG
  • Specificity: No cross reactivity with other proteins.
  • Applications Notes: Western blot, 0.1-0.5μg/ml, Mouse, Rat, Human
  • Subcellular Location: Cell membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single- pass type I membrane protein . Secreted . A secreted form is produced through proteolytic processing.
  • Protein Name: Tumor necrosis factor receptor superfamily member 1A