Anti-CD370 Purified CLEC9A Monoclonal Antibody

Anti-CD370 Purified CLEC9A Monoclonal Antibody

• Background: CD370 / CLEC9A, also known as DNGR1, is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged, such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system.
• Description: Boster Bio Anti-CD370 Purified CLEC9A Monoclonal Antibody (Catalog# M04577). Tested in Flow Cytometry, ICC application(s). This antibody reacts with Human.
• Synonyms: CLEC9A, DNGR1, DNGR-1, UNQ9341
• CAS Number: 9007-83-4
• Gene Name: CLEC9A
• UniProt: Q6UXN8
• Host: Mouse
• Reactivity: Human
• Immunogen: RBL-2H3 cells expressing human CLEC9A fused to an HA epitope. The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1), a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
• Clonality: Monoclonal
• Applications: Flow Cytometry, ICC
• Purification: Purified by protein-A affinity chromatography.
• Concentration: 1 mg/ml
• Form: Liquid
• Molecular Weight: 27324 MW
• Components: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Storage Conditions: Store at 2-8°C. Do not freeze.
• Fragment: Mouse IgG2a
• Clone ID: Clone: 8F9