Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody

Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody

• Background: CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
• Description: Boster Bio Anti-Hu CD161 Purified KLRB1 Monoclonal Antibody (Catalog# M03917-1). Tested in Flow Cytometry, WB, IHC-F application(s). This antibody reacts with Primate, Human.
• Synonyms: NKRP1A, KLRB1, CLEC5B
• CAS Number: 9007-83-4
• Gene Name: KLRB1
• UniProt: Q12918
• Host: Mouse
• Reactivity: Primate, Human
• Immunogen: Human NK cells. The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.
• Clonality: Monoclonal
• Applications: Flow Cytometry, WB, IHC-F
• Purification: Purified by protein-A affinity chromatography.
• Concentration: 1 mg/ml
• Form: Liquid
• Molecular Weight: 25415 MW
• Components: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Storage Conditions: Store at 2-8°C. Do not freeze.
• Fragment: Mouse IgG1 kappa
• Clone ID: Clone: HP-3G10