Anti-SREBF1 Antibody

Anti-SREBF1 Antibody

• Background: The sterol regulatory element binding transcription factor 1 (SREBF1) is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis (1). The related protein SREBF2 also binds SRE1 and activates transcription in an additive fashion to SREBF1 (2). SREBF1 is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1 (3). The SREBF1 proteins are important in the regulation of genes involved in lipid metabolism, while SREBF2 has been more closely associated with cholesterol synthesis and accumulation (4).
• Description: Boster Bio Anti-SREBF1 Antibody (Catalog # A00282). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
• Synonyms: SREBP1, bHLHd1, SREBP-1c, BHLHD1, SREBP1, Sterol regulatory element-binding protein 1, Class D basic helix-loop-helix protein 1, SREBP-1
• CAS Number: 9007-83-4
• Gene Name: SREBF1
• UniProt: P36956
• Host: Rabbit
• Reactivity: Human, Mouse
• Cross Reactivity: SREBF1 antibody is human and mouse reactive. At least three isoforms of SREBF1 are known to exist. SREBF1 antibody is predicted not to cross-react with SREBF2.
• Immunogen: SREBF1 antibody was raised against a 17 amino acid peptide near the center of human SREBF1. The immunogen is located within amino acids 450 - 500 of SREBF1.
• Clonality: Polyclonal
• Applications: ELISA, WB, IHC-P, IF
• Purification: SREBF1 antibody is affinity chromatography purified via peptide column.
• Concentration: 1 mg/mL
• Form: Liquid
• Molecular Weight: 121675 MW
• Components: SREBF1 antibody is supplied in PBS containing 0.02% sodium azide.
• Storage Conditions: SREBF1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
• Fragment: IgG