Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated
CAT:
763-PKSH033906-01
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated
- Background: FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
- Abbreviation: FcRn;B2M
- Synonyms: FCRN, IgG receptor FcRn, Neonatal Fc receptor
- CAS Number: 9000-83-3
- Accession Number: AAF72596&P61769
- Host: HEK293 Cells
- Origin Species: Human
- Tag: C-His-Avi
- Sequence: Ala24-Ser297&Ile21-Met119
- Applications: BLI
- Field of Research: Cardiovascular;Cancer
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Loaded Biotinylated Human FcRn Heterodimer-His-Avi on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 0.11 uM as determined in BLI assay.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 35&13 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.