Recombinant Human M-CSF/CSF1 Protein (His Tag)

Recombinant Human M-CSF/CSF1 Protein (His Tag)

• Background: Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. CSF-1 is required for normal male and female fertility and promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. it also plays a role in lipoprotein clearance.
• Abbreviation: M-CSF;CSF1
• Synonyms: CSF-1, CSF1, Lanimostim, M-CSF, MCSF, Macrophage Colony-Stimulating Factor 1, SCF-1
• CAS Number: 9000-83-3
• UniProt: P09603
• Accession Number: P09603
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Glu33-Arg255
• Applications: Cell culture
• Field of Research: Cardiovascular;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED₅₀ for this effect is 4.16 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 41 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.