Recombinant Human TMED1 Protein (Fc Tag)

Recombinant Human TMED1 Protein (Fc Tag)

• Background: TMED1 belongs to the EMP24/GP25L family. It contains 1 GOLD domain and is widely expressed. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS. TMED1 may play a role in vesicular protein trafficking; mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.
• Synonyms: IL1RL1LG, Il1rl1l, Tp24
• CAS Number: 9000-83-3
• UniProt: Q13445
• Accession Number: Q13445
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-hFc
• Sequence: Met 1-Asn194
• Applications: ELISA
• Field of Research: Cell biology
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: Immobilized mouse ST2-His at 10μg/mL (100μL/well) can bind human TMED1-Fc, the EC50 of human TMED1-Fc is 0.05-0.2μg/mL.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 57 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.