Human Tumor-Associated Calcium Signal Transducer 2, TACSTD2 Primacu™ ELISA Kit

Human Tumor-Associated Calcium Signal Transducer 2, TACSTD2 Primacu™ ELISA Kit

• Background: TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
• Description: Tumor-associated calcium signal transducer 2
• Synonyms: GA733-1;M1S1;TROP2
• Gene Name: TACSTD2
• Gene ID: 4070
• UniProt: P09758
• Origin Species: Human
• Reactivity: Human
• Target: TROP2
• Field of Research: Cancer
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 3.5 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 5.47-350 pg/mL
• Sensitivity: 1.23 pg/mL
• Weight: 35709
• Storage Temperature: 2-8°C