Lurasidone (Hydrochloride)

Lurasidone (Hydrochloride)

• CAS Number: 367514-88-3
• UNSPSC Description: Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
• Target Antigen: 5-HT Receptor; Dopamine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Lurasidone-Hydrochloride.html
• Purity: 99.96
• Solubility: DMSO : 6.67 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 80°C)|Ethanol : 2 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C([C@H]([C@H]1CC[C@@H]2C1)[C@H]2C3=O)N3C[C@@H]4CCCC[C@H]4CN(CC5)CCN5C6=NSC7=CC=CC=C76.Cl
• Molecular Weight: 529.14
• References & Citations: [1]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.|[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.ACS Chem Neurosci. 2020 Jan 15;11(2):173-183.|Marmara Pharm J. 2017;21 (4): 931-937.|Antibiotics (Basel). 2024 Mar 28, 13(4), 308.|bioRxiv. 2024 Jan 14.|J Med Chem. 2024 Apr 25;67(8):6144-6188.|J Ocul Pharmacol Ther. 2024 Aug 29.|Marmara Pharm J. 2017;21 (4): 931-937.|Marmara Pharm J. 2017;21 (4): 931-937.|Nature. 2023 Dec;624(7992):672-681.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched