Loxapine-d8 (hydrochloride)
CAT:
804-HY-17390BS-02
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Loxapine-d8 (hydrochloride)
- CAS Number: 1246820-19-8
- UNSPSC Description: Loxapine-d8 (hydrochloride) is the deuterium labeled Loxapine. Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][2].
- Target Antigen: 5-HT Receptor; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Solubility: 10 mM in DMSO
- Smiles: ClC=1C=C2C(=NC=3C(OC2=CC1)=CC=CC3)N4C(C(N(C)C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H].Cl
- Molecular Weight: 335.86
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35.|[3]Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30.|[4]Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85.|[5]Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported