A2AR/A2BR antagonist 1

A2AR/A2BR antagonist 1

• UNSPSC Description: A2AR/A2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A2AR/A2BR, with the IC50 values of 11.2 nM and 6.4 nM for A2AR and A2BR, respectively. A2AR/A2BR antagonist 1 promotes T cell-mediated cancer cell death[1].
• Target Antigen: Adenosine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/a2ar-a2br-antagonist-1-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=NC(C2=CN(N=N2)CC3=CNC4=C3C=C(C=C4)C#N)=CC(C5=CC=CC(C#N)=C5C)=N1
• Molecular Weight: 431.45
• References & Citations: [1]Wang H, et al. Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. J Med Chem. 2024 Mar 28;67(6):5075-5092.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported