Rociletinib hydrobromide
CAT:
804-HY-15729A-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rociletinib hydrobromide
- CAS Number: 1446700-26-0
- UNSPSC Description: Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
- Target Antigen: EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/CO-1686-hydrobromide.html
- Solubility: DMSO : ≥ 59 mg/mL|H2O : < 0.1 mg/mL
- Smiles: C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O.[H]Br
- Molecular Weight: 636.46
- References & Citations: [1]Walter AO, et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Sep 25.
- Shipping Conditions: Room Temperature
- Clinical Information: Phase 3