Rat Anti-Mouse CCL-17 Monoclonal Antibody
CAT:
209-103-M323
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rat Anti-Mouse CCL-17 Monoclonal Antibody
- Description: Human thymus and activationregulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse CCL17 was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse CCL17 cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24-29% amino acid sequence identity with RANTES, MIP1α, MIP1β, MCP1, MCP2, MCP3, and I309. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse CCL17 is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant CCL17 has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, CCL17 was identified to be a specific functional ligand for CCR4 and CCR8, receptors that are selectively expressed on T cells.
- Synonyms: Ccl17; Tarc; Abcd-2; Scya17; Scya17l
- CAS Number: 9007-83-4
- NCBI Gene ID: 20295
- UniProt: Q9WUZ6
- Accession Number: NP_035462
- Accession Number mRNA: NM_011332
- Gene Location: 8 C5; 8 45.0 cM
- Host: Rat
- Origin Species: Mouse
- Species Reactivity: Mouse
- Target Antigen: Recombinant Mouse CCL-17
- Isotype: IgG2
- Clone: (#9K49)
- Validated Applications: WB, N
- Purification Method: Protein G/A chromatography
- Form: Lyophilized
- Buffer: PBS
- Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- Shipping Conditions: Room Temperature
- Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.