2,3-Diphospho-D-glyceric acid (pentasodium salt)

2,3-Diphospho-D-glyceric acid (pentasodium salt)

• CAS Number: 102783-53-9
• UNSPSC Description: 2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/2-3-diphospho-d-glyceric-acid-pentasodium-salt.html
• Smiles: O=P(O[Na])(O[Na])OC[C@H](C(O[Na])=O)OP(O[Na])(O[Na])=O
• Molecular Weight: 375.95
• References & Citations: [1]Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.
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