Reserpine

Reserpine

• CAS Number: 50-55-5
• UNSPSC Description: Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
• Target Antigen: Autophagy; Monoamine Transporter
• Type: Natural Products
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/Reserpine.html
• Purity: 99.88
• Solubility: DMSO : 25 mg/mL (ultrasonic)
• Smiles: O=C([C@H]([C@@H](OC)[C@H](OC(C1=CC(OC)=C(OC)C(OC)=C1)=O)C[C@]2([H])CN3CC4)[C@@]2([H])C[C@]3([H])C5=C4C(C=CC(OC)=C6)=C6N5)OC
• Molecular Weight: 608.68
• References & Citations: [1]Antkiewicz-Michaluk L, et al. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54.|[2]Hong B, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18(3):659-69.|[3]Sreemantula S, et al. Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacol. 2004 Nov 16;4:30.|[4]Pfeiffer CJ, et al. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacol. 1980 Feb;61(4):347-53.|[5]Li GJ, et al. Preventive Effect of Polysaccharide of Larimichthys crocea Swim Bladder on Reserpine Induced Gastric Ulcer in ICR Mice. Korean J Physiol Pharmacol. 2014 Apr;18(2):183-90. |[6]Gupta MB, et al. Mechanism of ulcerogenic activity of reserpine in albino rats. Eur J Pharmacol. 1974 Jul;27(2):269-71. |[7]Park BK, et al. Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression. Biomed Res Int. 2018 Jun 26;2018:5845491.|[8]El-Marasy SA, et al. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chem Biol Interact. 2021 Jan 25;334:109329.Biomed Pharmacother. 2024 Jul:176:116856.|Br J Cancer. 2024 Jul 5.|Crit Rev Anal Chem. 2021 Mar 10;1-15.|Nigerian Journal of Scientific Research. 18 (3): 2019.|Phytomedicine. 2024 Sep 1.|Ren Fail. 2024 Dec;46(2):2406395.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Launched