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TSI-01

CAT:
804-HY-112825-04
Size:
50 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
TSI-01 - image 1

TSI-01

  • CAS Number: 704878-75-1
  • UNSPSC Description: TSI-01 is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s=0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). 60 μM it is shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.
  • Target Antigen: Others
  • Type: Reference compound
  • Related Pathways: Others
  • Applications: COVID-19-immunoregulation
  • Field of Research: Inflammation/Immunology
  • Assay Protocol: https://www.medchemexpress.com/tsi-01.html
  • Purity: 98.31
  • Solubility: DMSO : 125 mg/mL (ultrasonic)
  • Smiles: O=C(C1=CC=C(N2C(C(Cl)=C(C2=O)Cl)=O)C=C1)OC(C)C
  • Molecular Weight: 328.15
  • References & Citations: [1]Tarui, et al. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. J. Lipid Res. 55(7), 1386-1396 (2014).
  • Shipping Conditions: Room Temperature
  • Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
  • Clinical Information: No Development Reported