Gly-Gly-Gly-PEG4-DBCO

Gly-Gly-Gly-PEG4-DBCO

• CAS Number: 2353409-80-8
• UNSPSC Description: Gly-Gly-Gly-PEG4-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Gly-Gly-Gly-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/gly-gly-gly-peg4-dbco.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)|Methanol : 50 mg/mL (ultrasonic)
• Smiles: O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCNC(CNC(CNC(CN)=O)=O)=O)=O
• Molecular Weight: 694.77
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported