HDAC6 degrader-3

• CAS Number:

  2785404-83-1

• UNSPSC Description:

  HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1].

• Target Antigen:

  HDAC; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-degrader-3.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CCCCCCCNC(COC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)=O)NC4=CC5=C(C=C4)N(C(C)=N5)CC6=C(C=C(C=C6)C(NO)=O)F.FC(F)(F)C(O)=O

• Molecular Weight:

  883.80

• References & Citations:

  [1]Laura Sinatra, et al. Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity. J Med Chem. 2022 Dec 22;65(24):16860-16878.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported