Anti-DUSP3

Anti-DUSP3

• Description: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
• CAS Number: 9007-83-4
• Reactivity: Human,Mouse,Rat
• Immunogen: Rabbit polyclonal DUSP3 (1) antibody was raised against a recombinate human DUSP3 protein 2-144aa (BC035701).
• Clonality: Polyclonal
• Type: Antibodies-Polyclonal
• Applications: WB,IHC,ELISA
• Concentration: 100ug/100ul
• Purity: Affinity purified
• Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Shipping Conditions: Ice Pack
• Storage Conditions: This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
• Specificity: Human and predicted against mouse and rat.