Recombinant Human IL28B (IFNL3)

• Description:

  Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

• CAS Number:

  9000-83-3

• Gene Name:

  IFNL3

• Gene Aliases:

  IL-28B, Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28C, IL-28C, ZCYTO22
  Recombinant Human Interleukin-28B (IFNL3)

• Gene ID:

  282617

• Accession Number:

  Q8IZI9

• Organism:

  Human

• Source:

  CHO cells

• Concentration:

  <1.0 EU/μg of recombinant protein as determined by the LAL method.

• Purity:

  >95% as determined by SDS-PAGE

• Solubility:

  A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

• Function:

  The activity was determined by a WISH cell viral resistance assay with a linear range of 4-20 ng/mL.

• Molecular Weight:

  23

• Shipping Conditions:

  Ambient Temperature

• Storage Conditions:

  The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

• Appearance:

  Lyophilized Powder

• Formulation:

  Recombinant Human Interleukin-28B was lyophilized from a 0.2 μm filtered PBS solution pH 7.4.