Anti-CD31 / PECAM-1 (Endothelial Cell Marker)(1A10), CF647 conjugate
CAT:
37-BNC470846-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-CD31 / PECAM-1 (Endothelial Cell Marker)(1A10), CF647 conjugate
- Description: CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
- Synonyms: EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: PECAM1
- Gene ID: 5175
- NCBI Gene ID: 376675 & 514412
- UniProt: P16284
- Cellular Locus: Plasma membrane
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain downstream of the signal sequence of the CD31 (PECAM-1)
- Target Antigen: CD31 | PECAM-1
- Clonality: Monoclonal
- Isotype: IgG1 κ
- Clone: 1A10
- Conjugation: CF647
- Source: Animal
- Field of Research: Angiogenesis, Cancer
- Positive Control: THP-1, Jurkat cells. Tonsil or Angiosarcoma.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: ~100 kDa (endothelium); ~130 kDa (platelets)
- Additionnal Information: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years