PD-L1/PD-1-IN-1

• CAS Number:

  2753642-49-6

• UNSPSC Description:

  PD-L1/PD-1-IN-1 (compound 8j) is a potent inhibitor of PD-L1/PD interaction, with IC50 [1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pd-l1-pd-1-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(C2=CC=C(CNC(CO)(CO)CO)C(OC)=C2)C=CC=C1C3=CC=C4OCCOC4=C3

• Molecular Weight:

  485.96

• References & Citations:

  [1]Damian Muszak, et al. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction. J Med Chem. 2021 Aug 12;64(15):11614-11636.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported