PTK7/β-catenin-IN-6

• CAS Number:

  1219439-82-3

• UNSPSC Description:

  PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC)[1].

• Target Antigen:

  Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ptk7-β-catenin-in-6.html

• Solubility:

  DMSO : 73.33 mg/mL (ultrasonic)

• Smiles:

  O=C(N1C2=C(NC(C1CC(NC3=CC=C(C(Cl)=C3)Cl)=O)=O)C=CC=C2)/C=C/C4=CC=CC=C4

• Molecular Weight:

  480.34

• References & Citations:

  [1]Ganier L, et al., Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported