β-NETA

• CAS Number:

  31059-54-8

• UNSPSC Description:

  β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC50=76 μM) and cholinesterase (ChE; IC50=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC50=1 mM)[1][2].

• Target Antigen:

  Apoptosis; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/beta-neta.html

• Purity:

  98.0

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C2C=CC=CC2=C1)CC[N+](C)(C)C.[I-]

• Molecular Weight:

  369.24

• References & Citations:

  [1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71.|[2]B V Sastry, et al. 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide and its beta-isomer: new selective, stable and fluorescent inhibitors of choline acetyltransferase. J Pharmacol Exp Ther. 1988 Apr;245(1):72-80.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported