PROTAC MDM2 Degrader-3

• CAS Number:

  2249750-23-8

• UNSPSC Description:

  PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase[1].

• Target Antigen:

  E1/E2/E3 Enzyme; MDM-2/p53; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-mdm2-degrader-3.html

• Purity:

  96.06

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  O=C(N1CC(N(CC(OCCOCCOCCOCCOC(CN2C(CN(C(N3[C@H](C4=CC=C(Cl)C=C4)[C@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[C@H](C8=CC=C(Cl)C=C8)[C@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

• Molecular Weight:

  1437.25

• References & Citations:

  [1]Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported