Fmoc-8-amino-3,6-dioxaoctanoic acid

Fmoc-8-amino-3,6-dioxaoctanoic acid

• CAS Number: 166108-71-0
• UNSPSC Description: Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fmoc-8-amino-3-6-dioxaoctanoic-acid.html
• Purity: 99.98
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(O)COCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
• Molecular Weight: 385.41
• References & Citations: [1]Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported