Belinostat

Belinostat

• CAS Number: 866323-14-0
• UNSPSC Description: Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
• Target Antigen: Autophagy; HDAC
• Type: Reference compound
• Related Pathways: Autophagy;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Belinostat.html
• Purity: 99.95
• Solubility: DMSO : 100 mg/mL (ultrasonic)|Ethanol : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=S(NC1=CC=CC=C1)(C2=CC(/C=C/C(NO)=O)=CC=C2)=O
• Molecular Weight: 318.35
• References & Citations: [1]Plumb JA, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histonedeacetylase inhibitor PXD101. Mol Cancer Ther. 2003 Aug;2(8):721-8.|[2]Qian X, et al. Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies. Mol Cancer Ther. 2006 Aug;5(8):2086-95.|[3]Chia S, et al. Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time. Nat Commun. 2017 Sep 5;8(1):435.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched