CARM1 degrader-1 (hydrochloride)

• UNSPSC Description:

  CARM1 degrader-1 hydrochloride is the hydrochloride salt form of CARM1 degrader-1 (HY-156152). CARM1 degrader-1 hydrochloride is a PROTAC degrader for co-activator associated argininemethyltransferase 1 (CARM1), which degrades CARM1 in a VHL- and proteasome-dependent manner with a DC50 of 8.1 nM. CARM1 degrader-1 hydrochloride inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, and thus inhibits breast cancer cell migration[1].

• Target Antigen:

  Histone Methyltransferase; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/carm1-degrader-1-hydrochloride.html

• Solubility:

  DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C([C@H]1N(C([C@@H](NC(CN2CCN(CC3CCN(CC4CCN(C(COC5=CC=C(OC6=CC=CC(C(N(C)CC7=CC(C8CCN(CCNC)CC8)=NC=C7)=O)=C6)C=C5)=O)CC4)CC3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C9=CC=C(C%10=C(C)N=CS%10)C=C9)C.Cl

• Molecular Weight:

  1316.14

• References & Citations:

  [1]Xie H, et al., Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders. J Med Chem. 2023 Sep 28;66(18):13028-13042.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported