TP-2

• UNSPSC Description:

  TP-2, a caltrop-like multicationic small molecule, is an antidote that can completely neutralize both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs). TP-2 is not only superior to protamine, has higher neutralization activity, but is also biocompatible[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/tp-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCOC1=C(C=CC(C2=CC=[N+](C=C2)CC3=CC=C(C(C4=CC=C(C=C4)C[N+]5=CC=C(C=C5)C6=CC(OCCN)=C(C=C6)OCCN)(C7=CC=C(C=C7)C[N+]8=CC=C(C=C8)C9=CC(OCCN)=C(C=C9)OCCN)C%10=CC=C(C=C%10)C[N+]%11=CC=C(C=C%11)C%12=CC(OCCN)=C(C=C%12)OCCN)C=C3)=C1)OCCN.[Cl-].[Cl-].[Cl-].[Cl-]

• Molecular Weight:

  1607.63

• References & Citations:

  [1]Zong Y, et al. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. J Med Chem. 2024 Feb 26.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported