TG2-179-1

• CAS Number:

  1135023-19-6

• UNSPSC Description:

  TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tg2-179-1.html

• Solubility:

  DMF : 2 mg/mL (ultrasonic;warming)

• Smiles:

  N#CC1=C(NC(CSC2=NN=C(C3=CC=C(Cl)C=C3)O2)=O)SC(C)=C1C4=CC=C(C=C4)F

• Molecular Weight:

  484.95

• References & Citations:

  [1]Minhwa Kang, et al. Targeting BAP1 with small compound inhibitor for colon cancer treatment. Sci Rep. 2023 Feb 8;13(1):2264.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported