PROTAC NCOA4 degrader-1

• UNSPSC Description: PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. (Red: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B))[1].
• Target Antigen: Ferroptosis; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-ncoa4-degrader-1.html
• Smiles: CN1CCN(C2=CC3=C(N=C(C4=CC(N5CCC6=CC(OCCOCCOCCOCCNC(CCCC(N[C@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)=O)=O)=O)=CC=C6C5)=CC=C4)N3)C=C2)CC1
• Molecular Weight: 1141.43
• References & Citations: [1]Jian’ai Ji, et al. Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition. Journal of Medicinal Chemistry 2024 67 (15), 12521-12533.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported