B7/CD28 interaction inhibitor 1

• CAS Number:

  635324-72-0

• UNSPSC Description:

  B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].

• Target Antigen:

  CD28

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ctla-4-inhibitor-1.html

• Purity:

  99.47

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C2=CC=C(F)C=C2)NC3=C4C(N(C)N=C4)=NC(C5=CC=CC(C(F)(F)F)=C5)=C31

• Molecular Weight:

  427.35

• References & Citations:

  [1]Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported