Anti-Cathepsin D (Tumor Marker)(CTSD/3276), CF647 conjugate
CAT:
37-BNC473276-100
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Cathepsin D (Tumor Marker)(CTSD/3276), CF647 conjugate
- Description: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: Cathepsin D; CTSD; Lysosomal aspartyl peptidase
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: CTSD
- Gene ID: 1509
- NCBI Gene ID: 654447
- UniProt: P07339
- Cellular Locus: Secreted (extracellular)
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)
- Target Antigen: Cathepsin D
- Clonality: Monoclonal
- Isotype: IgG2b κ
- Clone: CTSD/3276
- Conjugation: CF647
- Source: Animal
- Applications: IF (verified) | IHC, FFPE (verified) | WB (verified)
- Validated Applications: IF, IHC, FFPE, WB
- Positive Control: MCF-7, K-562, A431 or SK-BR3 cells. Kidney, liver, lung or breast.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 46 kDa (Procathepsin D); 28 kDa (Cathepsin D)
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years