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Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2838)

CAT:
37-BNUB2838-500
Size:
500 µL
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2838) - image 1
Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2838) - image 2
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Anti-Desmoglein-3 (Squamous Cell Marker)(DSG3/2838)

  • Description: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Synonyms: 130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)
  • CAS Number: 9007-83-4
  • UNSPSC: 41116161
  • UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
  • Gene Name: DSG3
  • Gene ID: 1830
  • NCBI Gene ID: 1925
  • UniProt: P32926
  • Cellular Locus: Plasma membrane
  • Host: Mouse
  • Species Reactivity: Human
  • Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
  • Target Antigen: Desmoglein-3
  • Clonality: Monoclonal
  • Isotype: IgG1 κ
  • Clone: DSG3/2838
  • Conjugation: Purified, with BSA
  • Disease: Tumor
  • Source: Animal
  • Applications: IHC, FFPE (verified)
  • Validated Applications: IHC, FFPE
  • Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
  • Concentration: 0.2 mg/mL
  • Buffer: PBS, 0.05% BSA, 0.05% azide
  • Molecular Weight: 130 kDa
  • Shipping Conditions: Room temperature
  • Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
  • Shelf Life: 2 years

Datasheet

MSDS