Anti-BMI1 (Oncogene and Stem Cell Marker)(BMI1/2690)

• Description:

  The B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) is a transcriptional receptor of the polycomb gene family involved in several cellular processes including cell-cycle regulation, apoptosis, and maintenance of adult and neoplastic stem cells by providing self-renewal capacity. Further, Bmi-1 expression has been associated with malignant transformation, tumor progression, metastatic disease, and poor prognosis in human malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms:

  BMI1; Polycomb complex protein BMI1; B lymphoma Mo MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; Polycomb group ring finger 4; RING finger protein 51
• CAS Number:

  9007-83-4
• UNSPSC:

  41116161
• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name:

  BMI1
• Gene ID:

  648
• NCBI Gene ID:

  380403
• UniProt:

  P35226
• Cellular Locus:

  Cytoplasmic|Nucleus
• Host:

  Mouse
• Species Reactivity:

  Human
• Immunogen:

  Recombinant fragment (around aa 142-326) of human BMI1 protein (exact sequence is proprietary)
• Target Antigen:

  BMI1
• Clonality:

  Monoclonal
• Isotype:

  IgG2a κ
• Clone:

  BMI1/2690
• Conjugation:

  Purified, with BSA
• Source:

  Animal
• Applications:

  IHC, FFPE (verified)
• Validated Applications:

  IHC, FFPE
• Field of Research:

  Cancer, Developmental biology
• Positive Control:

  HeLa or Jurkat cells. Colon Carcinoma.
• Concentration:

  0.2 mg/mL
• Buffer:

  PBS, 0.05% BSA, 0.05% azide
• Molecular Weight:

  ~41 kDa
• Shipping Conditions:

  Room temperature
• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life:

  2 years