Anti-CD134, Mouse (OX40)(OX-86)

Anti-CD134, Mouse (OX40)(OX-86)

• Description: CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4 and CD8 T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4 T cell responses in vivo and in vitro. CD134 is expressed on activated CD4 T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: CD134; IMD16; Lymphoid activation antigen (ACT35); OX40 cell surface antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4); Txgp1l
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene ID: 22163
• NCBI Gene ID: 13885
• UniProt: P47741
• Cellular Locus: Plasma membrane
• Host: Rat
• Species Reactivity: Mouse
• Immunogen: Purified recombinant Mouse OX-40 antigen
• Target Antigen: CD134,
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: OX-86
• Conjugation: Purified, with BSA
• Source: Animal
• Applications: Flow, surface (published) | Functional studies (published) | IF (published) | WB (published)
• Validated Applications: FC, IF, WB
• Positive Control: MPBMC's. Spleen, Thymus or Lymph Node.
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.05% BSA, 0.05% azide
• Molecular Weight: ~50 kDa
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (2000) 164:2160-2169. (functional studies) Exp Med (2003) 198(5): 737-746. (Flow, surface) Am J Respir Crit Care Med (2010) 181: 688-698. (WB) J Leukoc Biol (2007) 81: 766-774. (IF)
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years