Nav1.7-IN-18

• UNSPSC Description:

  Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, showing analgesic effects in transgenic mice with inherited erythromelalgia (IEM)[1].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nav1-7-in-18.html

• Smiles:

  C[C@H]1[C@H](C[C@H]([C@@H]1C(O)=O)C(C2=C(C=C(C(C3CC3)=C2)OCC4CCN(CC4)CC5=C(C=CC=C5Cl)Cl)F)=O)F

• Molecular Weight:

  580.49

• References & Citations:

  [1]Shaoyi Sun, et al. Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7. Bioorg Med Chem Lett. 2025 Feb 1:116:130033.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported