DAPT (GMP)

• Product Name Alternative:

  GSI-IX (GMP)

• CAS Number:

  208255-80-5

• UNSPSC Description:

  DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor[1][2].

• Target Antigen:

  γ-secretase

• Type:

  GMP Small Molecules

• Related Pathways:

  Neuronal Signaling;Stem Cell/Wnt

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dapt-gmp.html

• Purity:

  99.3

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1

• Molecular Weight:

  432.46

• References & Citations:

  [1]Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312.|[2]Qi Y, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported