c-Fms-IN-8

• CAS Number:

  1255303-58-2

• UNSPSC Description:

  c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM[1].

• Target Antigen:

  c-Fms

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/c-fms-in-8.html

• Purity:

  99.47

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OCCOC1=CC=NC(C(N2CC(C3=CC=C(OCC4=CC=C(CC)C=C4)C(OC)=C3)C2)=O)=C1

• Molecular Weight:

  462.54

• References & Citations:

  [1]Ikegashira K, et al. Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models. Bioorg Med Chem Lett. 2019 Jan 1;29(1):115-118.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported