ATR-IN-4

• CAS Number:

  2574545-45-0

• UNSPSC Description:

  ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].

• Target Antigen:

  ATM/ATR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/atr-in-4.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CN1C(C2=CC(N3[C@@H](COCC3)C)=NN4C2=CN=C4C5=NNC=C5)=CC=N1

• Molecular Weight:

  364.40

• References & Citations:

  [1]Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported