PROTAC BcI-2/BcI-xI Degrader-1

• CAS Number: 3034200-49-9
• UNSPSC Description: PROTAC BcI-2/BcI-xI Degrader-1 (15) is a PROTAC based BcI-2/BcI-xI degrader (Red: BcI-2/BcI-xI inhibitor (HY-158677), black: linker, Blue: E3 ligase ligand)[1].
• Target Antigen: Bcl-2 Family; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-bci-2-bci-xi-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NC(C1=CC=C(N2[C@@](CO3)([H])CN(CC2)CC4=C(C5=CC=C(C=C5)Cl)CCC(C)(C4)C)C3=C1)=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCN(CC8)C(CCCCCC(N[C@@H](C(C)(C)C)C(N9[C@@H](C[C@H](C9)O)C(NCC%10=CC=C(C%11=C(N=CS%11)CCO%12)C%12=C%10)=O)=O)=O)=O)=O
• Molecular Weight: 1584.35
• References & Citations: [1]Dongping, et al. Chimeric compound used for targeted degradation of bcl-2 protein, preparation method therefor, and pharmaceutical application thereof. Patent. WO2024067818A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported