Rodatristat

Rodatristat

• Product Name Alternative: KAR5417
• CAS Number: 1673568-73-4
• UNSPSC Description: Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].
• Target Antigen: 5-HT Receptor; Tryptophan Hydroxylase
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/rodatristat.html
• Purity: 99.11
• Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O
• Molecular Weight: 561.98
• References & Citations: [1]Goldberg DR, et al. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 2