PROTAC ATR degrader-2

• CAS Number:

  3010273-12-5

• UNSPSC Description:

  PROTAC ATR degrader-2 (Compound 8i) is a PROTAC degrader for ATR, through of . PROTAC ATR degrader-2 degrades ATR in acute myeloid leukemia (AML) cells MV-4-11 and MOLM-13, with DC50 of 22.9 and 34.5 nM. APROTAC ATR degrader-2 induces apoptosis, inhibits proliferations of AML cells. PROTAC ATR degrader-2 exhibits good pharmacokinetics charachers and antitumor efficacy against AML in mouse model. (Pink: ATR ligand (HY-161616); Blue:E3 ligase ligand Lenalidomide (HY-A0003); Black: linker)[1]

• Target Antigen:

  Apoptosis; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-atr-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NC(C2=CC=C(C(N3CCN(CCCCC(NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)CC3)=O)C=C2)=CN=C1N)NC7=CC=CC=C7

• Molecular Weight:

  743.81

• References & Citations:

  [1]Wang Y, et al., Discovery of Selective and Potent ATR Degrader for Exploration its Kinase-Independent Functions in Acute Myeloid Leukemia Cells. Angew Chem Int Ed Engl. 2024 Apr 22;63(17):e202318568.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported