Spike Trimer Neutralizing Antibody (B.1.617.2, B.1.617.2.1, WT and B.1.1.7 Variants) (Clone hC-A11) (SARS-CoV-2)

• Description:

  This antibody is a humanized monoclonal antibody which recognizes SARS-CoV-2 spike RBD and the full-length spike proteins in the native trimeric conformation. This antibody is derived from rabbit monoclonal C-A11 neutralizing antibody (BPS Bioscience, #101024) . It cross-reacts with the wildtype as well as the B.1.617.2 (Delta Variant), B.1.617.2.1 (Delta PLUS Variant), B.1.1.7 (Alpha Variant) RBDs and spike protein trimers [Table of variants]. The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike RBD: ACE2 Inhibitor Screening Kits (available for purchase) .

• CAS Number:

  9007-83-4

• Applications:

  The humanized monoclonal neutralizing IgG can be used for functional assays testing inhibitors against SARS-CoV-2 Spike protein and ACE2 binding.

• Purification:

  Protein A

• Format:

  Aqueous buffer solution

• Shipping Conditions:

  +4°C

• Storage Conditions:

  4°C.  Stable for at least 6 months from date of receipt.

• Specificity:

  The antibody neutralizes the wildtype, B.1.1.7 (Alpha), B.1.617.2 (Delta) and B.1.617.2.1 (Delta Plus) variants of SARS-CoV-2 Spike RBD and Trimeric proteins

• Formulation:

  PBS