CFTR Recombinant Antibody / Cystic Fibrosis Transmembrane Regulator

CFTR Recombinant Antibody / Cystic Fibrosis Transmembrane Regulator

• Description: Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
• CAS Number: 9000-83-3
• UniProt: P13569
• Host: Rabbit
• Immunogen: A portion of amino acids 258-385 was used as the immunogen for the recombinant CFTR antibody.
• Clonality: Monoclonal
• Isotype: IgG
• Type: Recombinant
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Aliquot the recombinant CFTR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This recombinant CFTR antibody is available for research use only.