HLA-DRB1 Antibody (MHC II)

HLA-DRB1 Antibody (MHC II)

• Description: This mAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
• CAS Number: 9007-83-4
• UniProt: P01911
• Host: Mouse
• Immunogen: Activated human peripheral blood mononuclear cells were used as the immunogen for the anti-HLA-DRB1 antibody.
• Clonality: Monoclonal
• Isotype: IgG2b κ
• Applications: IHC-P
• Format: Purified
• Buffer: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
• Reconstitution: Store the anti-HLA-DRB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This anti-HLA-DRB1 antibody is available for research use only.