PROTAC BTK Degrader-1

• CAS Number:

  2801715-13-7

• UNSPSC Description:

  PROTAC BTK Degrader-1 is a potent, selective and orally active PROTAC BTK degrader with an IC50 value of 34.51 nM and 64.56 nM for BTK WT and BTK-481S, respectively. PROTAC BTK Degrader-1 effectively reduces BTK protein levels and suppresses tumor growth[1]. PROTAC BTK Degrader-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Btk; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-btk-degrader-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(C#CCN4CCC(CC4)N5CCC(CC5)N6N=C(C7=C(N=CN=C76)N)C8=CC=C(C=C8)OC9=CC=CC=C9)=C3

• Molecular Weight:

  749.86

• References & Citations:

  [1]Zhang J, et al. Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma. J Med Chem. 2022 Jun 7.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported