Desmorpholinyl Navitoclax-NH-Me

• Product Name Alternative:

  Desmorpholinyl ABT-263-NH-Me

• CAS Number:

  2365172-82-1

• UNSPSC Description:

  Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557)[1][2].

• Target Antigen:

  Bcl-2 Family; Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/desmorpholinyl-navitoclax-nh-me.html

• Purity:

  98.64

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCNC)C=C5)(=O)=O

• Molecular Weight:

  918.55

• References & Citations:

  [1]Guangrong Zheng, et al. Agents de dégradation de protéines bcl-2 pour le traitement du cancer. WO2019144117A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported