PTK7/β-catenin-IN-2

• CAS Number:

  902434-29-1

• UNSPSC Description:

  PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM[1].

• Target Antigen:

  β-catenin

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ptk7-β-catenin-in-2.html

• Solubility:

  DMF : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(CCC1=C(C)N2N=C(C3=CC=C(Cl)C=C3)C=C2N=C1C)NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5

• Molecular Weight:

  565.54

• References & Citations:

  [1]Ganier L, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer[J]. ACS Chemical Biology, 2022, 17(5): 1061-1072.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported